In Spring of this year, Kate Strong – a globally recognised adventure activist – set about organising a world-record breaking river clean-up. On March 21st, 1,327 people came together to clean the river across eight official locations as part of the #TaffTidy campaign. Cotton Mouton Diagnostics (CMD) supported the project by analysing water samples taken at each location to investigate how endotoxin levels vary along its course. The findings shed light on the complex relationship between environmental factors and bacterial contamination, offering insights for future water quality monitoring.

This blog outlines the validation process to demonstrate that a manufacturing facility or cleanroom consistently yields endotoxin-free outputs.

Ensuring the quality and purity of parenterally administered pharmaceutical drugs and medical devices is a key prerequisite for patient safety and for the generation of reliable and accurate laboratory results.

Endotoxins, which are strong pyrogens, are a component of the outer membrane of gram-negative bacteria. They are shed by gram-negative bacteria primarily during cell lysis and are widespread in the environment.